Amoxicillin + Clavulanic Acid

Beta-lactam Antibiotic Combination

Generic Name

Amoxicillin + Clavulanic Acid (Clavulanate)

Drug Class

Aminopenicillin with beta-lactamase inhibitor

Indications

Respiratory tract infections (sinusitis, pneumonia, bronchitis)
Otitis media
Urinary tract infections
Skin and soft tissue infections
Bone and joint infections

Dosage

Adults: 500/125 mg every 8 hours OR 875/125 mg every 12 hours
Children: 20–45 mg/kg/day of amoxicillin component, divided every 8–12 hours

Note: Adjust dose in renal impairment and according to infection severity.

Route of Administration

Oral (tablet, suspension), IV for severe infections

Mechanism of Action

Amoxicillin inhibits bacterial cell wall synthesis, while clavulanic acid inhibits beta-lactamase enzymes, extending amoxicillin's spectrum against resistant bacteria.

Common Adverse Effects

Diarrhea
Nausea, vomiting
Skin rash
Abdominal discomfort

Serious Adverse Effects

Anaphylaxis
Severe hypersensitivity reactions
Clostridioides difficile–associated diarrhea
Hepatic dysfunction (rare)

Contraindications

Hypersensitivity to penicillins or beta-lactamase inhibitors
History of cholestatic jaundice or hepatic dysfunction with this drug

Precautions

History of allergy or asthma
Renal impairment (dose adjustment needed)
Monitor for diarrhea and liver function if prolonged use

Drug Interactions

Allopurinol – increased risk of rash
Oral contraceptives – effectiveness may be reduced
Warfarin – may increase anticoagulant effect

Pregnancy & Lactation

Generally safe in pregnancy and breastfeeding if used as directed.

Patient Counseling

Complete the full prescribed course
Take with food to reduce gastrointestinal upset
Report rash, diarrhea, or jaundice immediately
Do not share medication with others