Cefadroxyl
Group
First-generation Cephalosporin
Mechanism of Action
Inhibits bacterial cell wall synthesis by binding to PBPs, leading to cell wall rupture and bacterial death.
Indications
- Pharyngitis and tonsillitis (Streptococcus pyogenes)
- Skin and soft tissue infections
- Urinary tract infections
- Bone and joint infections (occasionally)
Dose
- Adults: 500 mg–1 g orally every 12 hours
- Children: 30 mg/kg/day in 2 divided doses
Major Side Effects
- Gastrointestinal upset (nausea, vomiting, diarrhea)
- Rash
- Pruritus
- Rare: Anaphylaxis
- Rare: Pseudomembranous colitis
Contraindications
- Hypersensitivity to cephalosporins
- Severe penicillin allergy (cross-reactivity possible)
Compatible Fluid
Not applicable (oral formulation)
Route of Administration
Oral
Type of Administration
Capsule, Tablet, or Suspension (may be taken with or without food)