Group
Antiepileptic drug (non-competitive AMPA receptor antagonist)
Mechanism of Action
Selective, non-competitive antagonist of AMPA glutamate receptors, reducing excitatory neurotransmission and preventing seizure propagation.
Indications
- Partial-onset seizures with or without secondary generalization (adjunctive therapy)
- Primary generalized tonic-clonic seizures
Dose
- Adults: Start 2 mg orally at bedtime; may increase in increments of 2 mg weekly up to 8–12 mg/day (max 12 mg/day).
- Children (≥12 years): Similar dosing schedule adjusted by weight and tolerance.
Major Side Effects
- Dizziness, somnolence, fatigue
- Weight gain, increased appetite
- Aggression, irritability, mood changes
- Falls and balance disturbances
Contraindications
- Hypersensitivity to perampanel
- Severe psychiatric disorders with risk of aggression or suicidal ideation
Compatible Fluid
Not applicable (available as oral tablets or suspension).
Route of Administration
- Oral (tablet, suspension)
Type of Administration
Chronic therapy – once daily at bedtime (not used for acute seizure control).