Group
Antiepileptic, Neuropathic pain agent (GABA analogue)
Mechanism of Action
Binds to the α2δ subunit of voltage-gated calcium channels in the CNS, reducing excitatory neurotransmitter release and decreasing neuronal excitability.
Indications
- Partial seizures (adjunctive therapy)
- Neuropathic pain (diabetic neuropathy, postherpetic neuralgia)
- Fibromyalgia
- Generalized anxiety disorder (GAD)
Dose
- Epilepsy/Neuropathic pain: Start 150 mg/day in 2–3 divided doses; may increase up to 300–600 mg/day.
- Fibromyalgia: 300–450 mg/day in divided doses.
- GAD: 150–600 mg/day in divided doses.
Major Side Effects
- Dizziness, somnolence
- Weight gain, increased appetite
- Peripheral edema
- Blurred vision
- Dry mouth
Contraindications
- Hypersensitivity to pregabalin
- Caution in renal impairment (dose adjustment required)
Compatible Fluid
Not applicable (oral preparation only – capsules and oral solution).
Route of Administration
- Oral (capsules, oral solution)
Type of Administration
Chronic therapy – taken daily in divided doses for seizure control, neuropathic pain, or anxiety disorders.