Desloratadine

Class: Second-generation antihistamine (H1-receptor antagonist), active metabolite of loratadine

Indications: Allergic rhinitis (seasonal & perennial), chronic idiopathic urticaria

Mechanism: Selectively blocks peripheral H1-receptors, preventing histamine-mediated allergic symptoms. Longer half-life than loratadine.

Dosage

• Adults & ≥12 yrs: 5 mg once daily
• Children 6–11 yrs: 2.5 mg once daily
• Children 1–5 yrs: 1.25 mg once daily
• Children 6 mo–11 mo: 1 mg once daily (for allergic rhinitis/urticaria)
• Max dose: 5 mg/day

Major Side Effects

• Headache
• Fatigue
• Dry mouth
• Pharyngitis
• Rarely somnolence

Contraindications

• Hypersensitivity to desloratadine, loratadine, or any component
• Severe renal impairment (dose adjustment may be required)

Compatible Solvent / Administration

• Oral tablets, syrup, orally disintegrating tablets
• Take with or without food, with water

Special Precautions

• Safe for long-term use in allergic conditions
• Minimal CNS penetration → very low sedation risk
• Pregnancy Category C – use only if clearly needed
• Safe for children ≥6 months under medical supervision