Ebastine
Class: Second-generation antihistamine (H1 receptor antagonist)
Indications
- Allergic rhinitis (seasonal & perennial)
- Chronic idiopathic urticaria
- Other allergic conditions involving histamine release
Dosage
- Adults & children ≥12 years: 10–20 mg once daily
- Children 6–12 years: 5–10 mg once daily (depending on weight)
- Children <6 years: Safety not established
Major Side Effects
- Headache
- Drowsiness (rare, less than first-generation antihistamines)
- Dry mouth
- Dizziness
- Rare: QT prolongation (high doses or predisposed patients)
Contraindications
- Known hypersensitivity to Ebastine or formulation components
- Severe hepatic impairment
- Caution in patients with cardiac arrhythmias or on QT-prolonging drugs
Compatible Solvent / Form
- Available as oral tablets (10 mg, 20 mg)
- Syrup (for pediatric use in some formulations)
- Take with or without food
Special Precautions
- Monitor in patients with hepatic dysfunction
- Use caution in elderly (sensitive to cardiac effects)
- Avoid concomitant use with potent CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
- Assess QT interval risk in cardiac patients
Key Point: Ebastine is a non-sedating antihistamine effective for long-term allergy management, with low risk of CNS side effects.