Loratadine

Class: Second-generation antihistamine (H1-receptor antagonist)

Indications: Allergic rhinitis, chronic idiopathic urticaria, atopic conditions, hay fever

Mechanism: Selectively blocks peripheral H1-receptors, reducing histamine-mediated symptoms. Minimally sedating compared to first-generation antihistamines.

Dosage

• Adults & ≥12 yrs: 10 mg once daily
• Children 6–11 yrs: 10 mg once daily
• Children 2–5 yrs: 5 mg once daily
• Children 6 mo–2 yrs: 2.5 mg once daily (for urticaria/rhinitis)
• Max dose: 10 mg/day

Major Side Effects

• Headache
• Fatigue
• Dry mouth
• Drowsiness (rare, less than cetirizine)
• Gastrointestinal upset

Contraindications

• Hypersensitivity to loratadine or any component
• Severe hepatic impairment (dose adjustment required)

Compatible Solvent / Administration

• Oral tablets, syrup, orally disintegrating tablets
• Can be taken with or without food, with water

Special Precautions

• Adjust dose in hepatic impairment
• Generally non-sedating, but caution if combined with alcohol or CNS depressants
• Pregnancy Category B – relatively safe
• Safe for children ≥6 months under medical supervision