Generic & Brand Names
Generic: Beclomethasone Dipropionate
Common Brands: Qvar®, Becloforte®, Beconase®
Drug Class
Inhaled Corticosteroid Anti-inflammatory Respiratory Agent Mechanism of Action
Beclomethasone binds to glucocorticoid receptors in airway cells, reducing inflammation, edema, and mucus production. It helps prevent asthma exacerbations and improves overall airway function.
Indications
- Maintenance therapy of asthma (mild, moderate, severe)
- Allergic rhinitis (nasal spray)
- Chronic obstructive pulmonary disease (adjunct therapy)
Dosage (General)
- Adults & Children >12 years: 100–400 mcg twice daily (inhalation)
- Children 6–12 years: 40–200 mcg twice daily
- Nasal spray (allergic rhinitis): 42–84 mcg per nostril once or twice daily
Rinse mouth after inhalation to prevent oral candidiasis.
Side Effects
- Oral candidiasis (thrush)
- Hoarseness / dysphonia
- Throat irritation
- Cough
- Rare systemic corticosteroid effects with high doses
Contraindications & Precautions
- Hypersensitivity to beclomethasone or other corticosteroids
- Active untreated infections (fungal, bacterial, viral)
- Use caution in tuberculosis or immunocompromised patients
Drug Interactions
- CYP3A4 inhibitors (e.g., ketoconazole) may increase systemic exposure
- Concurrent systemic corticosteroids increase risk of adverse effects
Pregnancy & Lactation
Considered relatively safe; use only if clearly indicated and benefits outweigh risks.
Key Notes
- Not for acute asthma attacks
- Regular inhalation improves asthma control
- Long-term inhalation reduces systemic steroid exposure compared to oral corticosteroids
References
- British National Formulary (BNF). Inhaled corticosteroids – Beclomethasone.
- British National Formulary for Children (BNFc). Asthma and allergic rhinitis.
- Kliegman RM, St. Geme JW. Nelson Textbook of Pediatrics, 22nd ed. Elsevier; Respiratory pharmacology.
- Katzung BG, Trevor AJ. Basic & Clinical Pharmacology, 15th ed. McGraw-Hill.