Hydrocortisone – Corticosteroid & Adrenal Hormone

Hydrocortisone

Corticosteroid for Inflammation, Shock, and Adrenal Insufficiency

Indication

Used in acute adrenal insufficiency, septic shock, severe asthma, anaphylaxis, and inflammatory conditions.

Available Form

Injection 100 mg, 500 mg; oral tablets 10 mg, 20 mg, 50 mg; IV infusion available in hospital settings.

Dosage

Adult (IV): 100–500 mg IV as bolus or infusion depending on condition. In septic shock: 200 mg/day divided doses or continuous infusion.

Pediatric (IV): 2–4 mg/kg/day divided doses; adjust based on clinical response.

⚡ Major Side Effects

Hyperglycemia
Hypertension
Fluid retention, edema
Immunosuppression, increased infection risk
Long-term: osteoporosis, adrenal suppression

🚫 Contraindications

Systemic fungal infections without antifungal therapy
Hypersensitivity to corticosteroids
Caution in active viral infections

💧 Compatible Solvent

IV injection can be diluted in 0.9% NaCl or 5% dextrose; administer slowly to prevent hypotension.

⚠️ Special Precautions

Monitor blood glucose, electrolytes, and blood pressure.
Use caution in patients with diabetes, hypertension, or peptic ulcer disease.
Taper gradually after prolonged therapy to avoid adrenal insufficiency.
Monitor for signs of infection due to immunosuppressive effect.