Generic & Brand Names
Generic: Mometasone Furoate
Common Brands: Asmanex®, Nasonex®, Elocon®
Drug Class
Inhaled Corticosteroid Anti-inflammatory Respiratory Agent Mechanism of Action
Mometasone binds to glucocorticoid receptors in airway cells, reducing inflammation, edema, and mucus production. It decreases bronchial hyperresponsiveness, improving airflow and preventing asthma exacerbations.
Indications
- Maintenance therapy of asthma (mild, moderate, severe)
- Allergic rhinitis (nasal spray)
- Chronic obstructive pulmonary disease (adjunct therapy)
Dosage (General)
- Adults (inhalation): 110–220 mcg twice daily (via inhaler)
- Children 6–11 years: 110 mcg twice daily
- Nasal spray (allergic rhinitis): 50–100 mcg per nostril once daily
Rinse mouth after inhalation to prevent oral thrush.
Side Effects
- Oral candidiasis (thrush)
- Hoarseness / dysphonia
- Throat irritation
- Cough
- Rare systemic corticosteroid effects at high doses
Contraindications & Precautions
- Hypersensitivity to mometasone
- Active untreated infections (fungal, bacterial, viral)
- Use caution in tuberculosis or immunocompromised patients
Drug Interactions
- CYP3A4 inhibitors (e.g., ketoconazole) may increase systemic exposure
- Concurrent systemic corticosteroids increase risk of adverse effects
Pregnancy & Lactation
Generally considered safe; use only if benefits outweigh risks.
Key Notes
- Not for acute asthma attacks
- Long-term inhalation reduces systemic steroid exposure compared to oral corticosteroids
- Regular use improves asthma control and reduces exacerbations
References
- British National Formulary (BNF). Inhaled corticosteroids – Mometasone.
- British National Formulary for Children (BNFc). Asthma and allergic rhinitis.
- Kliegman RM, St. Geme JW. Nelson Textbook of Pediatrics, 22nd ed. Elsevier; Respiratory pharmacology.
- Katzung BG, Trevor AJ. Basic & Clinical Pharmacology, 15th ed. McGraw-Hill.