| Generic Name | Amlodipine Besylate + Calcium (Ā± Vitamin Dā) |
|---|---|
| Drug Class | Calcium Channel Blocker (Dihydropyridine) + Calcium Supplement |
| Indications |
|
| Mechanism of Action | Amlodipine: Inhibits calcium influx into vascular smooth muscle ā vasodilation ā ā BP Calcium: Essential for bone mineralization and neuromuscular function |
| Available Strengths | ā¢ Amlodipine 5 mg + Calcium Carbonate 500 mg ā¢ Amlodipine 10 mg + Calcium Carbonate 500 mg (Formulation may vary by manufacturer) |
| Dosage (Adult) | Start: 5 mg once daily Maximum: 10 mg once daily |
| Route | Oral |
| Common Side Effects |
|
| Serious Adverse Effects | Severe hypotension, marked edema, hypercalcemia (rare) |
| Contraindications | Hypersensitivity to amlodipine, severe hypotension, cardiogenic shock |
| Precautions | Hepatic impairment, elderly patients, heart failure |
| Drug Interactions | Other antihypertensives, grapefruit juice, calcium reduces absorption of tetracyclines and fluoroquinolones |
| Pregnancy & Lactation | Pregnancy: Use only if benefit outweighs risk Lactation: Use with caution |
| Storage | Store below 30Ā°C, protect from light and moisture |
| References | BNF | Manufacturer Prescribing Information | Goodman & Gilman |