Dicycloverine

Antispasmodic / Anticholinergic

Generic Name

Dicycloverine (also called Dicyclomine)

Drug Class

Anticholinergic, antispasmodic agent

Indications

Irritable bowel syndrome (IBS)
Functional bowel disorders with smooth muscle spasm
Colicky abdominal pain due to gastrointestinal spasms

Dosage

Adults: 10–20 mg orally 3–4 times daily
Children ≥6 years: 5–10 mg orally 3–4 times daily
Maximum daily dose: 80 mg for adults

Note: Dose should be individualized based on response and tolerance. Use caution in elderly patients.

Route of Administration

Oral (capsule, tablet, syrup), intramuscular (rarely)

Mechanism of Action

Dicycloverine is an anticholinergic that inhibits muscarinic receptors in the gut, reducing smooth muscle spasms and relieving abdominal pain associated with IBS.

Common Adverse Effects

Dry mouth
Blurred vision
Constipation
Dizziness
Urinary retention

Serious Adverse Effects

Severe anticholinergic toxicity (confusion, hallucinations)
Severe urinary retention
Seizures (rare)

Contraindications

Hypersensitivity to dicycloverine or other anticholinergics
Obstructive uropathy
Severe ulcerative colitis
Glaucoma (narrow-angle)
Myasthenia gravis

Precautions

Use with caution in elderly, those with cardiovascular disease, or impaired liver/kidney function
Avoid activities requiring alertness if dizziness or blurred vision occurs
Monitor for constipation or urinary retention

Drug Interactions

Other anticholinergic drugs – additive effects
Tricyclic antidepressants – increased anticholinergic side effects
Phenothiazines – additive CNS effects

Pregnancy & Lactation

Use only if clearly needed; safety not well established. Excreted in breast milk – monitor infant for anticholinergic effects.

Patient Counseling

Take 30 minutes before meals if possible
Avoid driving if dizzy or vision blurred
Report urinary retention, severe constipation, or confusion
Do not exceed prescribed dose