💊 Esomeprazole

Proton Pump Inhibitor (PPI)
Generic Name Esomeprazole
Drug Class Proton Pump Inhibitor
Indications
  • Gastro-esophageal reflux disease (GERD)
  • Erosive esophagitis
  • Peptic ulcer disease
  • Helicobacter pylori eradication (with antibiotics)
  • NSAID-induced ulcer prophylaxis
  • Zollinger–Ellison syndrome
Mechanism of Action Irreversibly inhibits the H+/K+-ATPase (proton pump) in gastric parietal cells, resulting in profound suppression of gastric acid secretion.
Available Forms & Strengths • Capsule / Tablet: 20 mg, 40 mg
• IV injection: 40 mg
Dosage Adults: 20–40 mg once daily (before meals)
Children: 0.5–1 mg/kg once daily (max 40 mg)
Route Oral, IV
Common Side Effects
  • Headache
  • Abdominal pain
  • Nausea
  • Diarrhea or constipation
Serious Adverse Effects Hypomagnesemia, vitamin B12 deficiency, Clostridioides difficile infection, increased fracture risk (long-term use)
Contraindications Hypersensitivity to esomeprazole or other PPIs
Precautions • Long-term therapy
• Hepatic impairment
• Osteoporosis risk
Drug Interactions • Clopidogrel (↓ antiplatelet effect)
• Warfarin
• Diazepam
• Phenytoin
Pregnancy & Lactation Pregnancy: Generally considered safe
Lactation: Use with caution
Storage Store below 30°C, protect from moisture
References BNF | BNF for Children | Goodman & Gilman
⚠️ Clinical note: Use the lowest effective dose for the shortest duration to reduce long-term adverse effects.
© DoseCalculator – Drug Reference