Prevention of motion sickness (less common with butyl bromide form)
Dosage
Adults: 10–20 mg orally, IM, or IV 3–5 times daily
Children: 0.3–0.6 mg/kg/day orally or IV in divided doses (use under medical supervision)
Maximum daily dose: 100 mg for adults
Note: Dose should be individualized based on severity and response. Use caution in elderly and patients with cardiac or liver disease.
Route of Administration
Oral, Intramuscular (IM), Intravenous (IV)
Mechanism of Action
Hyoscine butyl bromide is a quaternary ammonium anticholinergic that blocks muscarinic receptors in the smooth muscles of the gastrointestinal and genitourinary tract, reducing spasms and pain.
Common Adverse Effects
Dry mouth
Blurred vision
Constipation
Dizziness
Flushing
Serious Adverse Effects
Severe anticholinergic toxicity (confusion, hallucinations)
Urinary retention
Severe hypotension (rare)
Contraindications
Hypersensitivity to hyoscine or other anticholinergics
Glaucoma (narrow-angle)
Myasthenia gravis
Obstructive uropathy
Precautions
Use with caution in elderly, patients with cardiac, liver, or kidney impairment
Avoid driving or operating machinery if dizziness or blurred vision occurs
Monitor for constipation or urinary retention
Drug Interactions
Other anticholinergic drugs – additive effects
Tricyclic antidepressants – increased anticholinergic side effects
Phenothiazines – additive CNS effects
Pregnancy & Lactation
Use only if clearly needed; limited human data available. Excreted in breast milk – monitor infant for anticholinergic effects.
Patient Counseling
Take as prescribed; do not exceed recommended dose
Report urinary retention, severe constipation, or confusion