Irritable bowel syndrome (IBS) with abdominal pain and cramps
Spasmodic gastrointestinal disorders
Functional bowel disorders with smooth muscle spasm
Dosage
Adults: 135 mg orally 3 times daily, 20 minutes before meals
Children: Safety and efficacy not well established; use only under medical supervision
Note: Dose should be individualized. Usually well tolerated; adjust if needed for elderly or sensitive patients.
Route of Administration
Oral (tablet, capsule)
Mechanism of Action
Mebeverine directly relaxes smooth muscles of the gastrointestinal tract without affecting normal peristalsis. It acts by inhibiting calcium influx in smooth muscle cells, reducing spasms and abdominal pain.
Common Adverse Effects
Headache
Nausea
Constipation or diarrhea (rare)
Skin rash (rare)
Serious Adverse Effects
Allergic reactions (rash, itching, swelling)
Severe gastrointestinal upset (very rare)
Contraindications
Hypersensitivity to mebeverine or any excipients
Obstruction of the gastrointestinal tract
Precautions
Use with caution in elderly patients
Monitor for allergic reactions during first doses
Drug Interactions
No significant drug interactions reported
Always check co-administered drugs for additive antispasmodic effects
Pregnancy & Lactation
Use only if clearly needed. Limited human data available; consult healthcare provider before use during pregnancy or breastfeeding.
Patient Counseling
Take 20 minutes before meals for best effect
Do not crush or chew tablets unless specified
Report any allergic reactions or persistent gastrointestinal symptoms