💊 Pantoprazole

Proton Pump Inhibitor (PPI)
Generic Name Pantoprazole
Drug Class Proton Pump Inhibitor
Indications
  • Gastro-esophageal reflux disease (GERD)
  • Erosive esophagitis
  • Peptic ulcer disease
  • NSAID-induced ulcer prophylaxis
  • Zollinger–Ellison syndrome
Mechanism of Action Irreversibly inhibits the H+/K+-ATPase proton pump in gastric parietal cells → decreases gastric acid secretion.
Available Forms & Strengths • Tablet: 20 mg, 40 mg
• IV injection: 40 mg
Dosage Adults: 40 mg once daily (before meals)
Children: 1 mg/kg once daily (max 40 mg)
Route Oral, IV
Common Side Effects
  • Headache
  • Abdominal pain
  • Nausea
  • Diarrhea or constipation
Serious Adverse Effects Hypomagnesemia, vitamin B12 deficiency, increased fracture risk (long-term therapy), Clostridioides difficile infection
Contraindications Hypersensitivity to pantoprazole or other PPIs
Precautions • Long-term use
• Hepatic impairment
• Osteoporosis risk
Drug Interactions • Clopidogrel (↓ antiplatelet effect)
• Warfarin
• Diazepam
• Phenytoin
Pregnancy & Lactation Pregnancy: Generally considered safe
Lactation: Use with caution
Storage Store below 30°C, protect from moisture
References BNF | BNF for Children | Goodman & Gilman
⚠️ Clinical note: Use the lowest effective dose for the shortest duration to reduce long-term adverse effects.
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