Generic & Brand Names
Generic: Cromolyn Sodium (Sodium Cromoglycate)
Common Brands: Intal®, Lomudal®, Nasalcrom®
Drug Class
Mast Cell Stabilizer Anti-allergic Anti-asthmatic Mechanism of Action
Cromolyn sodium stabilizes mast cell membranes and prevents release of inflammatory mediators such as histamine and leukotrienes. It has no bronchodilator action and is used for prophylaxis.
Indications
- Prophylaxis of bronchial asthma
- Exercise-induced bronchospasm (prevention)
- Allergic rhinitis
- Allergic conjunctivitis
- Food allergy (oral formulation)
Dosage (General)
- Inhalation: 20 mg, 4 times daily
- Nasal spray: 1 spray each nostril, 4–6 times daily
- Eye drops: 1–2 drops, 4 times daily
- Oral (food allergy): As advised by specialist
Regular use is required for full benefit.
Side Effects
- Throat irritation
- Cough or bronchospasm (rare)
- Nasal irritation
- Headache
- Nausea
Contraindications & Precautions
- Hypersensitivity to cromolyn sodium
- Not effective for acute asthma attacks
- Should not replace rescue bronchodilators
Pregnancy & Lactation
Considered relatively safe. Use if benefit outweighs risk.
Key Notes
- Delayed onset of action (2–4 weeks)
- Very safe for pediatric use
- Used mainly as preventive therapy
References
- British National Formulary for Children (BNFc). Respiratory system – Cromoglycate. Latest edition.
- Kliegman RM, St. Geme JW. Nelson Textbook of Pediatrics, 22nd ed. Elsevier; Chapter: Asthma pharmacotherapy.
- Katzung BG, Trevor AJ. Basic & Clinical Pharmacology, 15th ed. McGraw-Hill; Anti-asthmatic drugs.
- Drug manufacturer prescribing information (Intal®).